Health Information

Major androgen is dehydroepiandrosterone.
The rest are adrostenedione and testosterone.
Estrogens & testosteron form in the circulation from Adrostenedione.

17-ketosteroid is formed and excreted with urine.
Two-third of urinary ketosteroids in man come from adrenal + liver. Only rest from testes.
Adrenal androgens are regulated by ACTH, not by gonadotropins.
Effect of androgen
Testosterone from testes is the most active androgen.
Adrenal androgens are 20% active as testicular androgen.
Adrenal androgens in normal concentrations has very little masculinizing effect.
In excessive amount make masculinizing effects.
Effect of androgen
Excessive secretion make masculinization.
Prepubertal boy – precocious pseudopuberty.
Adult male – accentuate existing characteristics.
Female – pseudohermaphroditism, adrenogenital syndrome.

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