Regulation of mineralocorticoids
Angiotensin II –
Act on synthesis of aldosterone.
No effect on cortisol.
In hemorrhage, standing, constriction of inferior vena cava, restriction of Na+ intake increase aldosterone secretion with renin-angiotensin pathway.
Plasma aldosterone is high when working in upright position due to
renin effect of postural.
decrease removal by the liver.
Those who confined to bed show circadian rhythm – high in early morning.
ANP – decrease responsiveness of Zona glomerulosa to angiotensin II.