Aldosterone
Protein bound fraction is low.
Aldosterone metabolized to glucuronide derivitatives.
Most in live and some in kidney.
These glucuronide can be converted back to aldosterone by acid pH.
Effects of Aldosterone
Na + reabsorption in urine, sweat, saliva and GIT.
Glucocorticoids can not act on minieralocoticoids receptor since the effect of enzyme 11ß-hydroxysteroid dehydrogenase type-2.
If the enzyme is inhibited/absent cortisol act as mineralocorticoid – apparent mineralocorticoid excess. (AME)