MYOCARDIAL INFARCTION
Ischemic syndromes may result,
(Depending on the rate of the development of the arterial narrowing.)
1. Angina Pectoris.
2. Myocardial Infarction. (MI)
– most important form.
3. Chronic Ischemic Heart Disease.
4. Sudden Cardiac Death.
MI is the most common cause of death in
industrialized nations.
MI almost always occurs in patients with
coronary atheroma.
Clinical diagnosis of acute MI based on
three sets of data.
I. Symptoms.
II. ECG changes.
III. Rise/Fall in cardiac enzyme.
I. Symptoms
Severe chest pain similar in character to angina.(20% of patients have no pain.)
II. ECG changes
ST elevation & T wave inversion.
III. Rise / Fall in cardiac enzymes
Necrotic cardiac tissue release several enzymes as
follows.
1. Creatinine Kinase. (CK)
2. Lactate Dehydrogenase. (LDH)
3. Aspartate Amino Transferase. (AST)(SGOT)
4. Cardiac specific Troponin.
I. Troponin I
II. Troponin T
5. Glycogen Phosphorylase –BB (GPBB)